These domains include the ovarian tumor (OTU) cysteine protease domain (pfam02338), the C-terminal catalytic domain of Ulp1 protease (pfam02902) and the plant homeodomain (PHD) finger motif (smart00249) from the Conserved Domain Database http://www.ncbi.nlm.nih.gov/sites/entrez?db=cdd (Table 1, Figure 1a, e, f). The gene discussed is CTSB; the disease is ovarian neoplasm.