Moreover, patients with advanced grade tumor (P, 0.50; HR, 1.49; CI, 0.46-4.89) having nodal metastasis (P, 0.42; HR, 1.63; CI, 0.49-5.34) along with RB1 deletion (P, 0.15; HR, 2.27; CI, 0.74-7.02) showed a trend to have poorer survival, albeit being statistically insignificant. This evidence concerns the gene RB1 and neoplasm.