Furthermore, serum antibodies to SS-A/Ro52 were detected, though no clinical signs of connective tissue disorders, such as Sjoegren syndrome or systemic lupus erythematodes, or of myositis were present in the patient, and no further extractable nuclear antigens such as nRNP/Sm, Sm, and SS-A/Ro-60, SS-B, Scl-70, PM-Scl, Jo-1, PCNA, double stranded DNA (dsDNA), centromer protein B (CEPB), nucleosomes, histones, and ribosomale P proteins were detectable. This evidence concerns the gene PCNA and connective tissue disorder.