For breast cancer, some of the genes reported to undergo hypermethylation are involved in evasion of apoptosis (DAPK, TWIST1, HOXA5), cell cycle regulation (p16, CCND2), cell invasion and metastasis (CDH1, APC), DNA repair (BRCA1) and cell signaling (ER and RARβ2) [2]. This evidence concerns the gene DAPK1 and breast cancer.