PTEN loss was found in 26.9%; PI3K-p110α was expressed in 66.3%; p-AKT, in 28.3%; p-p70S6K, in 75.8%; p-S6, in 62.7%; p-RAF, in 45.7%; p-p44/42 MAPK, in 26.8%; and HSP90, in 63.5% of the 212 tissue samples of invasive breast cancers (Table 2; Figure 1). This evidence concerns the gene RPS6KB1 and invasive breast carcinoma.