To achieve our goals, we over-expressed either wildtype or dominant negative forms of MKP-1 in a NSCLC cell line, H441GL which contains dual reporter genes, enhanced green fluorescence protein (G) and firefly luciferase (L), to assess its impact both in vitro and in vivo, as well as the pharmacological induction of MKP-1 by rosiglitazone. The gene discussed is DUSP1; the disease is non-small cell lung carcinoma.