CD247 and HIV-1 infection: The only reports of ITAM protein expression in the context of HIV infection have been older observations that HIV-1 infection in patients not receiving cART was associated with decreased expression of TCRζ (an ITAM-signalling protein that mediates T-cell receptor signaling) in bystander cells that are not necessarily infected by HIV-1, including NK and CD8+ T cells [10], [11], [12].