CD4 and malaria: Flow cytometric analysis also showed a significant increase on CD4+CD25+FoxP3+ T cells producing IFN-γ (P<0.0001), IL-17 (P = 0.0020), TGF-β (P<0.0001) and IL-10 (P<0.0001) (Figures 2C to 2F) in malaria-infected individuals.