The single specificities that are able to initiate lupus autoimmunity include at least the autoimmune responses against 60 kD Ro, nRNP A, dsDNA, phospholipid, and ribosomal P. For lupus the initiating autoantogens do not generally include nRNP 70 K or Sm. The gene discussed is CALR; the disease is systemic lupus erythematosus.