Antibodies to common lupus antigens as detected by this solid-phase, bead-based assays were detectable prior to antibodies against cardiolipin (APL), Rheumatoid Factor (RF), and C1q in the majority of patients in which both were present (n = 79, n = 98, and n = 85, respectively). Here, FASLG is linked to systemic lupus erythematosus.