Collectively, these results show that ErbB2 and ErbB3 control basal, constitutively active levels of pAkt and down regulation of ErbB2 and ErbB3 contributes to α-TEA-induced suppression of pAkt and induction of apoptosis in both A2780S and A2780/CP70R human ovarian cancer cells. This evidence concerns the gene ERBB2 and ovarian carcinoma.