Hypoxia is a major activator of angiogenesis in tumours [2]; the hypoxic state of cells promotes the up-regulation of a variety of cytokines and tumour suppressors, such as p53 and also of hypoxia-inducible factor 1-alpha, primarily known for its ability to activate Vascular Endothelial Growth Factor (VEGF) expression [3]. The gene discussed is HIF1A; the disease is neoplasm.