Interestingly, VEGF-C along with VEGF-A and a variety of pro-angiogenic cytokines have been shown to be released from tumour associated macrophages, whose infiltration is thought to be, at least in part, responsible for the angiogenic switch in tumours whereby the balance of pro- and anti-angiogeneic factors favour a pro-angiogenic phenotype [8-10]. This evidence concerns the gene VEGFA and neoplasm.