In fact, the alternative SNPSpD approach [20], which takes into account LD patterns between genotyped SNPs in the tested population, may be more appropriate since the 21 genotyped MMP-2 SNPs are not independent; with this approach, the significance of association of two specific SNPs with stroke, in the ischemic subset or in the overall population sample, was retained after multiple testing correction. The gene discussed is MMP2; the disease is stroke disorder.