Here we present data showing although some physiological differences exist the action of artemisinin on malaria does in principle mirror many aspects of that on yeast: artemisinin can fast act to depolarize the mitochondrial membrane in malaria parasite as in yeast; rapid and dramatic reactive oxygen species (ROS) production is induced with artemisinin in isolated malarial and yeast but not mammalian mitochondria; inhibition of the NADH dehydrogenase in the mitochondrial ETC antagonizes the action of artemisinin in malaria parasite. The gene discussed is ENSG00000254051; the disease is malaria.