A study of the relationship between the expression of NCAM and the anti-oncogene DPC4, and CCA NI, showed that the NCAM expression rate in CCA with NI was significantly higher than in CCA without NI, indicating that NCAM is related to CCA NI and might play a critical role in the nerve invasion process[28]. The gene discussed is NCAM1; the disease is cholangiocarcinoma.