On multivariate analysis (age, KPS and extent of surgical excision), PSA-NCAM expression was the unique predictive parameter of OS [hazard ratio (HR): 2.01 for patients suffering from a GBM with PSA-NCAM content >10 pg/μg of protein (CI:1.01-4); p = 0.046, n = 56] and DFS [HR: 2.89 for patients suffering from a GBM with PSA-NCAM content >10 pg/μg of protein (CI:1.34-6.27); p = 0.007, n = 54]. Here, NCAM1 is linked to glioblastoma.