Based on the good bioavailability of bortezomib [27], we extrapolated the above studies to in vivo experiments of low-dose (100 ng/kg = 0.1 mg/kg) bortezomib treatment of C57BL/6 mice bearing LLC-induced subcutaneous tumors or MPEs, aiming to block tumor cell NF-κB activation without affecting cell proliferation. The gene discussed is NFKB1; the disease is neoplasm.