Analysis in relation to conventional prognostic indices of PCa showed a negative correlation with Gleason grade; Wnt-11 was more frequently found in Gleason 3 tumours than in Gleason 4 tumours and in Gleason < 8 compared to Gleason > 8, suggesting that Wnt-11 is not a general marker for tumour dedifferentiation. The gene discussed is WNT11; the disease is posterior cortical atrophy.