Based on the association of HLA-DRB1*0405 and HLA-DRB1*0410 alleles with VKH disease, we propose that the epitope S57-LLEQRRAA (67–74) in the third hypervariable region of the HLA-DRβ1 molecule is the relevant susceptibility epitope. The gene discussed is HLA-DRB1; the disease is Vogt-Koyanagi-Harada disease.