The composite TFBS pair, STAT*Pax-2, was over-represented in three co-expressed genes; 34FL, PAG2, and PTGS2. The PWM for the predicted STAT binding site is common to a range of STAT proteins that are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumor surveillance. The gene discussed is PTGS2; the disease is neoplasm.