The pooled analysis suggested a possible association in Caucasians (for Val/Val and Val/Leu combined, OR = 1.5, 95% CI: 1.1, 2.1), with effect modification across age categories.26 Our finding of an association between CYP1B1 codon 432 (G→C) and breast cancer is consistent with the results of several studies in Caucasians.24,26 In our study, the risk of breast cancer in individuals with the homozygous CC mutation or the heterozygous GC mutation was increased 2.79 (95% CI: 1.04 to 7.51)- and 1.69 (95% CI: 0.92 to 3.08)-fold, respectively, compared to that of individuals with wild-type GG. This evidence concerns the gene CYP1B1 and breast cancer.