CD38 and B-cell chronic lymphocytic leukemia: It is therefore tempting to speculate that peculiar biological features of the residual T cell component in CLL, as it could be identified by the variable expression of specific markers, e.g. CD38, telomeres, CD25 and CD54 [41-45] or, as shown here, ZAP-70, might be the result of interactions of T cells themselves with CLL cells, which might eventually contribute to define the clinical features of the disease [40,46].