For example, acute lymphoblastic leukemia (ALL) is characterized by the following specific alterations: t(12;21)(p13;q22) [ETV6/RUNX1], high hyperdiploidy (HeH, >50 chromosomes), t(1;19)(q23;p13) [TCF3/PBX1], and t(9;22)(q34;q22) [BCR/ABL1], whereas acute myeloid leukemia (AML) is characterized by t(8;21)(q22;q22) [RUNX1/RUNX1T1], t(15;17)(q22;q21) [PML/RARA], and inv(16)(p13q22) [CBFB/MYH11]. This evidence concerns the gene PML and acute myeloid leukemia.