BRCA1 and breast carcinoma: Decreased BRCA1 mRNA expression in breast cancer cell lines, as determined by real-time quantitative polymerase chain reaction (RT-QPCR), enhances cisplatin sensitivity but leads to resistance to paclitaxel and vinorelbine via defective apoptotic response to these drugs, while the opposite phenomenon is observed in the presence of normal or high levels of BRCA1 [15].