Interestingly, many of the over-represented functional categories of up-regulated genes associated with poor prognosis were shared with up-regulated genes in aneuploidy, high centrosome aberrations and CD34+CD38+ AML fraction, and down-regulated genes in euploidy, low centrosome aberrations, NPM1 mutations, good prognosis AML, CD34+CD38- AML fraction, and FLT3-ITD. The gene discussed is CD38; the disease is acute myeloid leukemia.