SEMA3F is a secreted protein that has been reported to function as a axon guidance factor, a tumor suppressor gene in small cell lung cancer, a inhibitor of angiogenesis, and a possible direct inhibitor of tumor cell migration and attachment.[93] Although there have been no previous reports describing SEMA3F expression in AML, our comparison included three papers that associated increased expression of SEMA3F with a good prognosis, which suggest that a SEMA3F analog could have potential for treatment in AML. The gene discussed is SEMA3F; the disease is acute myeloid leukemia.