Even though the primary cytoskeletal networks appeared intact, we tested the mRNA expression levels of routinely used cardiac hypertrophy markers such as atrial natriuretic factor (ANF), b-type natriuretic factor (BNF), β-myosin heavy chain sarcoplasmic reticulum calcium pump isoform 2A (SERCA2a) and phospholamban by QPCR. This evidence concerns the gene NPPA and cardiac hypertrophy.