LYN and familial pancreatic carcinoma: In particular, gemcitabine resistance in pancreatic cancer is often associated with high expression of focal adhesion kinase (FAK) [8], a protein involved in metastasis; and elevated expression and activity of Src Family Kinases (SFK), including SRC and Lyn, have also been reported in numerous human cancer cell lines and tumour tissues [9]–[11].