ANGPT2 and cerebral malaria: Recently, increased circulating ANG-2 levels were associated with severe and cerebral malaria in three distinct populations [28]–[30], while ANG-1 levels and the ratio of ANG-2/ANG-1 were shown to differentiate between individuals with cerebral malaria and those with uncomplicated malaria, in addition to predicting mortality in Ugandan children with cerebral malaria [29].