ANGPT2 and infection: Transcription of Angpt2 and the ratio of Angpt2/Angpt1 was significantly increased in placentas of infected mice (2-way ANOVA: infection, P = 0.0063 and P = 0.0031, respectively; Fig. 2), and Angpt1 showed a trend towards decreased expression in placentas of infected as compared to uninfected mice (2-way ANOVA: infection, P = 0.056).