Using recombinant autoantigens, PBC sera was found to react more frequently with p62 (55%) than gp210 (10%) nucleoporin [25] and that more than 50% of PBC sera precipitated 35S-radioactively labeled p62 recombinant rat or human nucleoporin, while 40% recognized this recombinant antigen by immunoblotting [26]. This evidence concerns the gene NUP210 and primary biliary cholangitis.