Furthermore, high densities of CD8+/granzymeB+ T cells and CD45+ memory T cells at the tumor margin and in the center of colorectal cancers were found to be a better predictor of patient survival than the histopathological methods usually used, leading to the hypothesis that not only the type but also density and location of tumor infiltrating T cells may be a more critical determinant for the prognosis [28,29]. The gene discussed is CD8A; the disease is colorectal cancer.