Furthermore, obesity was associated with reduced levels of RIP140 mRNA in adipocytes (obese N = 5, 0.87 ± 0.12 log10 AU vs. lean N = 5, 1.12 ± 0.10 log10 AU, P > 0.01). Here, NRIP1 is linked to obesity due to melanocortin 4 receptor deficiency.