S100A8 and gastric cancer: The cag (cytotoxin-associated gene) pathogenicity island (cagPAI) in H. pylori contains 31 putative genes [5] and encodes a type IV secretion system that delivers CagA into the cytosol, which is phosphorylated and activates phosphatase activity to initiate morphological changes of the cell, providing a potential mechanism by which chronic H. pylori infection may promote the development of gastric cancer [6].