EDCs are also able to stimulate the glucocorticoid receptor (GR) and as glucocorticoid signaling is central to adipocyte differentiation, they are able to promote adipogenesis in the 3T3-L1 Cell Line through the activation of the GR, thus leading to obesity [38]. The gene discussed is NR3C1; the disease is obesity due to melanocortin 4 receptor deficiency.