Although vascular immunohistochemical (IHC) markers such as CD31[27,28], Factor VIII[9,10], Ulex europaeus[8] and CD34[27,29] have been used to identify vascular invasion in malignant neoplasms, the diagnostic value of these vascular markers compared to a specific lymphatic IHC marker, D2-40, in FTC has not been investigated [30,31]. The gene discussed is PDPN; the disease is thyroid cancer, nonmedullary, 2.