To the best of our knowledge EMILIN2 and CIDE-A methylation in primary tumours has not been previously reported, SALL1 and FBLN2 methylation has been previously reported in acute lymphocytic leukemia [11,12] and DBC1 methylation has been reported in NSCLC, bladder cancer, oral cancer and in leukaemia [9,13-15]. This evidence concerns the gene FBLN2 and urinary bladder carcinoma.