A recent study analyzed the TRAF1/C5 variant, rs3761847, in relation to mortality in RA and observed an increased mortality risk for the susceptible genotype GG compared with the non-susceptible AA genotype (hazard ratio (HR) = 3.96, 95% confidence interval (CI) = 1.24 to 12.6) [10]. The gene discussed is TRAF1; the disease is rheumatoid arthritis.