TRARG1 and neoplasm: This model was based largely on the putative tumor suppressor features of Tusc5 (see above), coincident expression of Tusc5 with adipocyte markers that increase as 3T3-L1 adipocytes exit the mitotic clonal expansion phase to terminally differentiate and mature [2], and the repression of Tusc5 expression in the “proliferative” brown adipose tissue (BAT) of cold exposed rodents ([4]; also see [2]).