AGT and Alzheimer disease: Increasing evidence for the roles of GRKs and angiotensin 1 and 2 (AT1 and AT2) in hypertension, stroke, and heart disease with association between these receptors/ligands in heart disease and AD [15], as well as early amyloid-β (Aβ) accumulation in vitro [16] and our in vivo work with models of hypoperfusion [8] prompts further consideration of AD and AD-like pathology in terms of possible inclusion and classification as disorders of the cerebrovasculature, because they involve common receptor types.