With this in mind, we investigate what role GRK2 may play in the early pathogenesis of dementia and determined the cellular, subcellular, and ultrastructural distribution and localization of GRK2 immunoreactivity in cases of human AD as well as in a mammalian model of chronic brain hypoperfusion (CBH), as first seen with light microscopy and confirmed by western blotting [8]. The gene discussed is GRK2; the disease is dementia.