It has been shown in vivo that diabetes increases FOXO1 DNA-binding activity and increases FOXO1 nuclear translocation in chondrocytes in fracture repair.(22) This is also shown in this study, but when TNF was inhibited, FOXO1 nuclear translocation was reduced, which may indicate that the effects of TNF on apoptosis is mediated through FOXO1. The gene discussed is FOXO1; the disease is diabetes mellitus.