A highly resourced study using a combined linkage and association analysis has linked the Bmp2 gene to a combined phenotype of low BMD and high fracture risk.(13) Polymorphisms in the Bmp4 gene are associated with senile osteoporosis.(14) In fact, several small-molecular-weight compounds have been identified by their stimulatory effect on Bmp2 gene expression. This evidence concerns the gene BMP2 and osteoporosis.