Estimated three-year OS rate and PFS rate were 92.2 ± 3.4% and 85.8 ± 4.3%, respectively, in patients with CML-CP who received imatinib as primary therapy; 81.3 ± 5.4% and 68.7 ± 6.3%, respectively, in CML-CP patients who had failed IFN-α; 46.8 ± 13.0% and 39.8 ± 13.2%, respectively, in AP patients and 19.6 ± 7.4% and 10.1 ± 6.5%, respectively, in BC patients (P < 0.0001 and P < 0.0001, respectively, for OS and PFS). The gene discussed is IFNA1; the disease is alkaline phosphatase measurement.