In the whole population, the multivariate analysis applied to the basal model (Table 4) showed, as expected, a significantly higher risk of metastasis associated with surgical tumour size of >20 mm (HR 3.00; P=0.002), lymph node-positive status (HR 2.93; P=0.002) and ER and/or PgR-negative status (HR 2.15; P=0.007). The gene discussed is PGR; the disease is neoplasm.