For instance, an FPR variant receptor, FPRL1, in monocytic cells (Lee et al, 2005) and a chemokine GPCR CXCR3 in colon cancer cells have also been shown to up-regulate MMP9 (Zipin-Roitman et al, 2007). This evidence concerns the gene CXCR3 and malignant colon neoplasm.