In a polulation-based, case-control study to identify the association between polymorphisms in PARP-1 and NHL risk in Koreans, we found that Val762Ala, Asp81Asp, and Lys352Lys polymorphisms and the haplotype-ACAAC in PARP-1 were associated with decreased risk of NHL in males. The gene discussed is PARP1; the disease is non-Hodgkin lymphoma.