PDPN and laryngeal carcinoma: In laryngeal carcinomas, podoplanin expression was generally heterogeneous and exhibited two different patterns, similar to previous observations in oral cancer [12]: 20 (38%) cases showed diffuse expression in most tumour cells (Fig. 1E) and 33 (62%) cases showed focal expression at the proliferating periphery of the tumour cell nests with no expression in the central areas (Fig. 1F).