The expression of podoplanin is up-regulated in a number of different human cancers, including squamous cell carcinoma of the oral cavity, the lung, the cervix, the oesophagus, and the skin, in dysgerminomas of the ovary and granulosa cell tumours, in mesothelioma, and in many tumours of the central nervous system (CNS) [5,7,9-12]). This evidence concerns the gene PDPN and squamous cell carcinoma.