There is extensive evidence that some HLA-DRB1 alleles, including HLA-DRB1*0101, HLA-DRB1*0102, HLA-DRB1*0401, HLA-DRB1*0404, HLA-DRB1*0405, HLA-DRB1*0408, HLA-DRB1*0410, HLA-DRB1*1001, HLA-DRB1*1402 are associated with susceptibility to RA. Here, HLA-DRB1 is linked to rheumatoid arthritis.