When the dataset was ranked according to differential expression in histopathological grade 3 cases vs. cases classified as grade 2&1, the following gene sets showed significant enrichment after correction for multiple testing: ERBB signaling (KEGG), NSCLC related signaling (KEGG), EGFR/SMRT (Biocarta), and FAS anti-apoptotic signaling (Biocarta). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.