The haplotype window of NFE2L2 consisting of the five consecutive tag SNPs 2-6 (rs7557529, rs2886161, rs1806649, rs2001350 and rs10183914) was strongly associated with risk of PD (pc = 0.008), as well as with AAO of the disease (pc = 0.003). The gene discussed is NFE2L2; the disease is Parkinson disease.