Although Hif-1α, which is stabilized and overexpressed in regions of hypoxia, has been shown to repress MYC levels in other systems [71], we did not find an increase in levels of Hif-1α staining either toward the lumens of cribriform neoplastic glands, nor at the invasive front of budding early adenocarcinoma lesions (T. Iwata, AM De Marzo, unpublished results). Here, HIF1A is linked to adenocarcinoma.