MYC and prostate intraepithelial neoplasia: Also similar to most human high grade PIN lesions, the glandular architecture of the PIN lesions in Lo-MYC mice generally showed either a single cell layer, was pseudostratified, or contained what appeared to be multiple layers; albeit even in multilayered appearing PIN lesions the cells largely maintained their polarity (see Figure 2 for direct comparison of mouse and human high grade PIN).