Perhaps this contributes to establishing pneumococcal carriage by supporting selective pneumococcal clearance by CLN>>spleen antigen-presenting cells after stimulation with CD4+ T cell-derived IL-10, whereas IFN-γ-secreting HTLs might support spleen>>CLN macrophages activation and/or internalization of S. pneumonia. The gene discussed is IFNG; the disease is susceptibility to pneumonia measurement.