To address these possibilities, thepresent study investigated the effects of limited glucose availability (usedhere to mimic the effects of calorie restriction), the Sirt1 activator(resveratrol), and the hormone dehydroepiandrosterone (DHEA), on expression ofSirt1 and TXNIP in different cellular systems, including cancer, stem cells anda mice model. Here, SIRT1 is linked to cancer.